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KMID : 0367320110220040253
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Journal of the Korean Academy of Child and Adolescent Psychiatry
2011 Volume.22 No. 4 p.253 ~ p.261
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An Open-Label Study of the Improvements in Clinical Symptoms and Neurocognitive Functions in Korean Children and Adolescents with Attention-Deficit Hyperactivity Disorder after Treatment with Metadate CD
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Yoo Han-Ik
Kim Bong-Seog
Joung Yoo-Sook
Bahn Geon-Ho
Song Dong-Ho
Ahn Dong-Hyun
Lee Young-Sik
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Abstract
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Objectives: This study aimed to investigate the efficacy and safety of Metadate CD (MCD) when given to Korean children and adolescents with attention-deficit hyperactivity disorder (ADHD). We also explored the effects of the drug on diverse neuro-cognitive functions.
Methods: Ninety-one subjects with ADHD (mean age 8.6 ± 2.2 years) were recruited at 6 outpatient clinics in Seoul, Korea. We used the ADHD Rating Scale (ARS), Clinical Global Impression (CGI), and comprehensive attention test (CAT) to measure the drug’s effects.
Results: After 0.92 ± 0.32mg/kg/day of MCD were administered for 57.4 ± 7.6 days, there was a 48.5% reduction in the mean total ARS scores (p<.001). Fifty-seven subjects (64.8%) showed either much improved or very much improved outcomes on the CGI-Improvement scale. The CGI-Severity scale also decreased from an average of 4.7 to an average of 2.9 (p<.001). Errors and response time standard deviations of the CAT, sustained attention test-to-response tasks, the flanker test, and divided attention test scores decreased after treatment (p<.05). The forward memory span of the spatial working memory test scores increased (p<.05). Thirty-five patients (39.8%) experienced side effects, of which the most common were headache (14.8%), nausea (12.5%), and anorexia (9.1%).
Conclusion: This open-label study suggests that MCD is effective and safe in improving the symptoms and neurocognitive functions of Korean children and adolescents with ADHD.
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KEYWORD
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ADHD, Metadate CD, Effectiveness, Safety, Comprehensive Attention Test
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